Sirtuin
A family of NAD+-dependent enzymes involved in stress response, gene regulation, mitochondrial function, and cellular repair.
Definition of “Sirtuin”
Sirtuins are a family of enzymes, often discussed as SIRT1 through SIRT7, that help regulate how cells respond to stress and manage repair. They influence gene expression, mitochondrial performance, inflammatory signaling, and how cells adapt to scarcity or damage.
They matter in supplement conversations because they sit at the center of several longevity narratives. Resveratrol is often discussed because it may influence SIRT1 activity. NMN and nicotinamide riboside matter because sirtuins require NAD+ as a cofactor. Once you understand sirtuins, many of the site's longevity pages start connecting into a coherent mechanism instead of reading like disconnected ingredient claims.
“Sirtuin” In Practice
Resveratrol plus an NAD+ precursor is a common pairing because the argument is not simply that both are popular, but that sirtuin biology gives the combination a shared mechanistic logic.
Worth Knowing About “Sirtuin”
Sirtuins are important, but they are often oversold. Influencing a longevity pathway is not the same thing as proving longer human lifespan or broad disease prevention.