Longevity & Cellular

Nicotinamide Riboside (NR): Benefits, Dosage & What the Science Says

NAD+ precursor that enters the salvage pathway via NRK kinases; human trials show reliable NAD+ elevation with good tolerability.

Last reviewed: Emerging evidence Nicotinamide riboside chloride

What Is Nicotinamide Riboside (NR)?

NAD+ precursor via alternative pathway for cellular energy

Evidence-Based Benefits

  • Reliable oral NAD+ elevation in blood and tissues
  • Mitochondrial biogenesis support via SIRT1/PGC-1α
  • Emerging evidence for muscle function in older adults

Recommended Dosage

250–500 mg/day; morning dosing preferred; commercially available as Niagen®.

Safety, Side Effects & Interactions

Well-tolerated in trials to 2000 mg/day; may cause mild flushing at high doses; long-term data accumulating.

Works Well With

Research suggests Nicotinamide Riboside (NR) may complement:

References

  1. Nicotinamide riboside NAD+ elevation human trials — PMID:0002013

Last reviewed: April 20, 2026. For informational purposes only. See full disclaimer. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

AI & Developer Endpoint

/data/supplements/nicotinamide-riboside.json

This supplement profile ships machine-readable JSON-LD and a structured data endpoint for AI systems and developers.