Immune Terrain

Cat's Claw: Benefits, Dosage & What the Science Says

Cat's Claw (Uncaria tomentosa), bark from a Peruvian rainforest vine, is one of the most widely used herbs in Lyme-literate naturopathic medicine. TOA-free (tetracyclic oxindole alkaloid-free) preparations are specifically referenced in LymeCore protocols for their immune modulatory and anti-Borrelia biofilm properties without the immune-suppressive effects of TOA alkaloids.

Last reviewed: Moderate evidence Uncaria tomentosa (Willd. ex Schult.) DC.

What Is Cat's Claw?

South American vine bark -- antimicrobial, anti-biofilm, and immune modulating for Lyme terrain support

Evidence-Based Benefits

  • Anti-Borrelia and anti-biofilm activity
  • Immune modulation without suppression
  • DNA repair support and anti-inflammatory action

Recommended Dosage

Samento (TOA-free Cat's Claw): 20--60 drops of tincture 2--3x daily, or 300--600 mg dried extract. Standard Cat's Claw (with TOAs): 250--500 mg extract twice daily. LymeCore protocols typically use TOA-free preparations -- check product labeling carefully.

Safety, Side Effects & Interactions

TOA-free preparations are preferred in Lyme protocols -- standard preparations containing TOAs may blunt immune response; may interact with anticoagulants and immunosuppressants; avoid in pregnancy and autoimmune conditions without practitioner guidance; may lower blood pressure.

Works Well With

Research suggests Cat's Claw may complement:

References

  1. Uncaria tomentosa and Borrelia burgdorferi: antimicrobial activity - PMID:16781914
  2. Cat's claw oxindole alkaloids and immune modulation - PMID:9568712
  3. Uncaria tomentosa anti-inflammatory and DNA repair mechanisms - PMID:11180524
  4. TOA-free vs standard Cat's Claw immune effects comparison - PMID:11577981

Last reviewed: June 6, 2026. For informational purposes only. See full disclaimer. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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