Immune Terrain

Andrographis: Benefits, Dosage & What the Science Says

Andrographis paniculata (Chuan Xin Lian) is a bitter Ayurvedic and TCM herb with one of the most studied antimicrobial profiles in botanical medicine. Andrographolide, its primary diterpene lactone, exhibits documented activity against Borrelia burgdorferi -- including persistent stationary-phase forms -- making it a cornerstone of LymeCore and Lyme-literate naturopathic protocols.

Last reviewed: Moderate evidence Andrographis paniculata (Burm.f.) Nees

What Is Andrographis?

Bitter TCM antimicrobial with clinical evidence for immune activation and Borrelia activity

Evidence-Based Benefits

  • Broad-spectrum antimicrobial and anti-Borrelia activity
  • Immune activation and interferon induction
  • NF-kappaB anti-inflammatory signaling

Recommended Dosage

400--1200 mg standardized extract daily (10% andrographolides); therapeutic Lyme-protocol doses often reach 1200--1800 mg/day in divided doses under practitioner supervision. Standard immune support: 400 mg twice daily.

Safety, Side Effects & Interactions

Well tolerated at standard doses; high doses may cause GI upset, headache, or metallic taste; rare allergic reactions reported; avoid in pregnancy and with immunosuppressants; andrographolide may lower blood pressure.

Works Well With

Research suggests Andrographis may complement:

Traditional Use

Traditional Chinese Medicine
穿心莲 Chuan Xin Lian
clears heat and resolves toxicity dries dampness reduces swelling cools the Blood clears Lung and throat heat

View herb profile on NaturalHerbLibrary.com →

References

  1. Andrographolide activity against Borrelia burgdorferi: in vitro study - PMID:30524929
  2. Andrographis paniculata immune activation: systematic review - PMID:21878854
  3. Andrographolide and NF-kappaB inhibition - PMID:16226828
  4. Andrographis in upper respiratory infections: meta-analysis - PMID:21210706

Last reviewed: June 6, 2026. For informational purposes only. See full disclaimer. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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